For the most part InD CS6 is pretty stable although I've had a few crashes. On occasion InDesign will hang up when I click to sign out of a Folio Builder account. Eventually I just have to force-quit InD. When I relaunch InD CS6 all my user preferences are lost, including all my Print Presets and Document Presets and InDesign restarts as though I'm launching it for the very first time. This has happened often enough now that I keep a good copy of my InDesign Defaults preference file on my desktop so I can copy it back to User/Library/Preferences/Adobe InDesign/Version 8.0/en_US folder before I relaunch. Sometimes I have to do this twice before InD will recognize my user preference file.
This never happened with older version of InDesign. If InDesign CS5 crashed or require a force-quit it would always relaunch with the last saved preference version. InDesign CS6 is actually updating the preference file each time I legitimately quit the application and everything is as it should be except when there is a crash or force-quit -- then it simply ignores the last-saved preference file and reverts to some "first-launch" preference. I have no idea why this is happening.
I'm hoping if someone there at Adobe can tell me if this is a bug that will be addressed in a future update, because I don't know what I can do other than keep my backup pref file handy. It's either that, or reload all the Saved Print Presets, Save Document Presets, and then go through the list of Preferences each time there is a crash or I have to force-quit.
I'm using an iMac 3.06 GHz Intel Core i3 with 4GB RAM, running Lion 10.7.5